Wednesday, February 19, 2025

Which drugs are effective for social phobia? (ChatGPT, 2025-2-19)

 Several medications have been found effective for social phobia (social anxiety disorder, SAD). The most commonly prescribed drug classes include:


1. Selective Serotonin Reuptake Inhibitors (SSRIs)

 First-line treatment for long-term management due to effectiveness and tolerability.

 Examples:

 Paroxetine (Paxil)

 Sertraline (Zoloft)

 Fluvoxamine (Luvox)

 Escitalopram (Lexapro)

 Takes 48 weeks to show effects.


2. Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

 Also first-line, especially if SSRIs are ineffective.

 Example:

 Venlafaxine XR (Effexor XR)

 Can help with both psychological and physical symptoms (e.g., blushing, sweating).


3. Beta-Blockers

 Used for performance anxiety (not generalized SAD).

 Reduce physical symptoms (e.g., heart rate, tremors).

 Examples:

 Propranolol (Inderal)

 Atenolol (Tenormin)

 Taken 3060 minutes before a performance or social event.


4. Benzodiazepines

 Short-term relief (used cautiously due to addiction risk).

 Examples:

 Clonazepam (Klonopin)

 Alprazolam (Xanax)

 Lorazepam (Ativan)

 Work immediately, but cause sedation and dependence.


5. Monoamine Oxidase Inhibitors (MAOIs)

 Reserved for severe cases or when other treatments fail.

 Examples:

 Phenelzine (Nardil)

 Tranylcypromine (Parnate)

 Require dietary restrictions (avoid tyramine-rich foods).


6. Atypical Antidepressants

 Mirtazapine (Remeron)  sometimes used off-label.

 Bupropion (Wellbutrin)  less effective for anxiety but may help if depression is also present.


7. Anticonvulsants (Off-label)

 Some evidence suggests benefit:

 Gabapentin (Neurontin)

 Pregabalin (Lyrica)  more promising, particularly for physical symptoms.


Which One Should You Choose?

 Generalized SAD: SSRIs or SNRIs first, with benzodiazepines for acute symptoms.

 Performance anxiety: Beta-blockers like propranolol.

 Severe, treatment-resistant cases: MAOIs (rarely used).

 Rapid relief: Benzodiazepines (but not for long-term use).


Would you like recommendations based on specific symptoms or concerns?