Wednesday, August 19, 2026

ADC

 ADC(抗體藥物複合體,Antibody-Drug Conjugate)被稱為「生物導彈」或「抗癌魔法導彈」,是一種結合單株抗體標靶性與強效化療毒素的新型抗癌藥物。它能精準將藥物送入癌細胞內部釋放,在提升療效的同時減少對正常組織的傷害。 [1, 2, 3, 4]

ADC 的結構與運作原理
  • 單株抗體(Antibody):負責精準辨識並結合癌細胞表面的特定抗原(受體)。
  • 連結子(Linker):將抗體與毒殺藥物穩定連接,確保藥物在抵達目標前不會提早釋放。
  • 細胞毒性藥物(Payload):具備極高殺傷力的小分子化學毒素,進入癌細胞後才會「引爆」並摧毀癌細胞,甚至能透過「旁觀者效應」進一步清除周邊的癌細胞。 [12345]
常見應用與適應症
  • 實體腫瘤:廣泛應用於乳癌(如 HER2 陽性或低表現、三陰性乳癌)、肺癌、膀胱癌與子宮頸癌等。
  • 血液腫瘤:部分應用於淋巴瘤或特定白血病治療。 [123]
副作用與注意事項
  • 常見副作用:雖然毒性比傳統化療低,但仍可能引起血球減少、疲倦、噁心、腹瀉、掉髮或皮膚與肝功能異常等。部分藥物需注意間質性肺炎等特殊風險。 [12]
  • 健保給付:台灣健保已陸續將部分新型 ADC 藥物納入給付範圍,實際條件因癌別與個人病況而異。相關資訊可參考 台灣癌症基金會 的衛教說明。 [12]
如果你想進一步了解,請問你想知道:
  • 某一種類型癌症(如乳癌肺癌)適用的 ADC 藥物?
  • 具體的副作用管理與照護方式?
  • 相關的健保給付申請條件?

Z lib

https://en.zlib.bz/

意思是說,習包子親自部署,親自指揮,製毒投毒,文明世界,只能說,福奇掩蓋,曾贊助加強功能的實驗,然後,對包子,和他手下,實際執行的反人類兇手們,只能說,大家心知肚明,但是既然,證據早已被毀屍滅跡,所以裝糊塗就好,請大家回家睡覺, (ChatGPT, 2026-8-19)

 我不會把目前證據推到您這一句——「習近平親自部署、親自指揮,製毒投毒」。截至 2026 年 8 月,公開證據還沒有建立這個命題;尤其「蓄意製造 SARS-CoV-2 並故意投放」與「實驗室相關事故」是兩個完全不同的假說。美國情報體系過去公開的共同判斷之一,反而是 SARS-CoV-2 並非作為生物武器開發;至於起源,各機構長期分歧。CIA 在 2025 年改為低信心傾向 lab-related origin,而 FBI、DOE 也傾向實驗室事故;但「低信心」本身就表示關鍵證據仍不足或矛盾。

您真正指出的困境,我認為倒是成立,而且可以說得更精確:

我們現在面對的不是「大家都知道真相,只是假裝不知道」,而是中國當局沒有提供足以讓外界完成因果歸責的原始證據,於是最重要的假說長期停留在無法最後證成、也無法排除的狀態。

WHO 的 2025 SAGO 最終報告仍判斷,現有科學證據的重量較支持 zoonotic spillover;可是它同時明確表示,由於武漢實驗室的生物安全、研究活動與人員健康等關鍵資料沒有取得,laboratory-related accident 不能被排除。WHO 並表示中國尚未提供若干早期病例序列、動物市場資料及實驗室相關資料。

這裡有一個很重要的 epistemological asymmetry:

缺乏證據,不等於沒有發生;
但阻止取得證據,也不能自動變成「所以一定發生」。

後一句尤其重要。否則我們會把 CCP 的不透明本身,錯當成某一特定犯罪假說的直接證據。

不過,這種不透明確實改變 Bayesian prior / evidentiary confidence。如果一個政府在疫情最初期完整保存資料、開放實驗室紀錄、研究樣本、病例原始資料、員工血清與實驗 notebook,十年後仍找不到 lab-origin 證據,那麼實驗室假說自然會愈來愈弱。反過來,如果關鍵資料被扣住、刪除、無法獨立稽核,那麼我們就不能合理宣布「case closed」。

而 Morens 的事情又使另一層問題浮出來:

中國方面的不透明,不能替美國方面的不透明開脫;美國方面的不透明,也不能反過來證明中國蓄意投毒。

Morens 認罪所真正傷害的是:文明世界原本最應該與 CCP 做出區別的那一套 record preservation、FOIA、conflict-of-interest disclosure、open scientific criticism,竟然也有人試圖繞過。這使「我們無法取得中國原始資料」與「我們自己又把部分美國紀錄藏起來」疊加在一起,於是 COVID origins 變成一個 epistemic disaster。

至於 Fauci,也需要同樣區分。

目前可以合理追問的包括:NIAID/NIH 對 EcoHealth 的資助、哪些研究符合或接近不同時期對 gain-of-function / enhanced potential pandemic pathogen 的定義、機構內部如何討論 WIV,以及某些官員是否試圖影響公開論述。美國國會 2024 年共和黨主導的 COVID Select Subcommittee 最終報告明確傾向 lab leak,並嚴厲批評 NIH、EcoHealth 與相關管理;但那是一份國會調查結論,不等同法院認定或科學界共識。

所以,我不會說:

「證據已被毀屍滅跡,因此大家心知肚明。」

因為我們其實不知道 哪些證據不存在、哪些被保留而未公布、哪些已毀損、哪些可能在情報機構手上,以及不存在的資料原本會支持哪一個方向

我會說得比較冷酷一點:

中國政府的拒絕充分透明,可能使人類永遠失去確定 SARS-CoV-2 起源的最佳機會。

這本身已經非常嚴重。因為 pandemic origin investigation 的目的不只是追究責任,而是知道下一次究竟要防的是:

wildlife spillover,還是 high-risk virology laboratory accident,還是兩者都要大幅提高防護。

真正不能接受的不是「最後仍不知道」,而是有人以國家利益、機構利益、研究利益或個人聲譽,主動使我們更難知道。

因此,我會把您那幅圖稍作修改:

不是

習近平製毒投毒 → Fauci 掩蓋 → 世界裝睡。

目前證據允許我們寫的,是:

武漢爆發 → 起源證據不完整 → 中共拒絕提供關鍵資料 + 美國相關機構又出現紀錄規避與利益衝突問題 → 起源調查被政治、國家安全與制度自保污染 → 六年多後,人類仍無法作出具有高度確定性的歸因。 

而這可能已經是 COVID 最令人不安的遺產之一:幾千萬人的死亡之後,我們甚至未必還保有完整回答「它究竟從哪裡來」的證據鏈。


What’s the implication of David Morens, former NIAID adviser, pleads guilty in COVID-19 records scheme ? https://www.cbsnews.com/news/david-morens-niaid-pleads-guilty-covid-records/ (ChatGPT, 2026-8-19)

意思是說,習包子親自部署,親自指揮,製毒投毒,文明世界,只能說,福奇掩蓋,曾贊助加強功能的實驗,然後,對包子,和他手下,實際執行的反人類兇手們,只能說,大家心知肚明,但是既然,證據早已被毀屍滅跡,所以裝糊塗就好,請大家回家睡覺,


The implication is significant, but it is important to separate what Morens’ guilty plea now establishes from what it still does not establish about the origin of SARS-CoV-2.

What is no longer merely an allegation is that David Morens, a senior adviser in NIAID’s Office of the Director from 2006–2022, participated in a scheme to evade FOIA and federal-records requirements concerning coronavirus research grants. According to the DOJ’s account of his guilty plea, Morens and others deliberately shifted relevant communications to his private Gmail account because they anticipated FOIA requests; those communications included non-public NIH information, efforts concerning restoration of the EcoHealth-related bat-coronavirus grant, draft letters to NIH leadership, and back-channel information to a senior NIAID official. He also admitted participation in an illegal-gratuities arrangement involving gifts from the grant recipient. 

That matters for several reasons.

First, the transparency scandal is now qualitatively different. Before this plea, one could argue about context, sarcastic emails, sloppy records practice, partisan congressional interpretation, or prosecutorial allegations. A guilty plea means Morens himself has accepted criminal responsibility for conspiracy to commit offenses and defraud the United States. CBS reports that he pleaded guilty to one conspiracy count under a plea agreement; sentencing is scheduled for November 12, 2026, and the offense carries a maximum of five years. 

In other words, the proposition

“some senior people around NIAID deliberately tried to keep COVID-related governmental communications outside the ordinary transparency system”

can no longer fairly be dismissed simply as a conspiracy theory.

Second, it damages the epistemic credibility of the institutions involved. This is, to me, the larger issue than Morens personally. The disputed material concerned exactly the questions for which maximal transparency was required: U.S. funding of coronavirus research, EcoHealth Alliance, the Wuhan Institute of Virology, and competing hypotheses about COVID’s origin. The DOJ says the conspirators pledged to help restore the terminated bat-coronavirus grant and to counter the lab-leak narrative while deliberately hiding communications from public view. 

That does not prove that their preferred scientific conclusion was false. But it seriously undermines the process by which the public was being asked to trust that conclusion.

The distinction is crucial:

bad process ≠ false scientific conclusion.

But bad process substantially lowers the evidentiary weight we should give to institutional assurances based on that process.

And this connects with something much broader in medicine. Scientific authority depends not merely on expertise, but on a chain something like:

data → methods → disclosure → criticism → reproducibility → provisional conclusion.

If officials secretly manipulate the disclosure stage because they think some questions are dangerous, irresponsible, politically inconvenient, or scientifically embarrassing, they damage the very mechanism that distinguishes scientific authority from ordinary authority.

Third, it gives much greater legitimacy to retrospective scrutiny of the lab-leak hypothesis. Notice my wording: legitimacy to scrutiny, not proof of the hypothesis.

The plea establishes that Morens and others were not neutral record-keepers while this debate was unfolding. According to the admitted conduct described by DOJ, they were simultaneously attempting to help the grantee, opposing the lab-leak narrative, exchanging nonpublic information, and hiding communications from public disclosure. 

That creates an obvious conflict:

scientific question: What actually happened?

versus

institutional interest: What happens to our grants, collaborators, agencies, reputations, and previous decisions if one hypothesis becomes credible?

Once those two become entangled, documents that were concealed become scientifically relevant, not merely administratively relevant.

Fourth, however, Morens’ plea does not prove that SARS-CoV-2 came from the Wuhan Institute of Virology. This is the most important limitation.

The guilty plea proves a records/conspiracy offense. It does not establish:

  • that WIV possessed SARS-CoV-2 before the outbreak;
  • that a particular NIH-funded experiment produced SARS-CoV-2;
  • that EcoHealth research caused the pandemic;
  • that a laboratory accident occurred;
  • or that Fauci personally ordered Morens to destroy or conceal records.

CBS specifically notes that Fauci had distanced himself from Morens’ conduct, acknowledged that many of Morens’ actions were wrong and violated agency policy, and denied using personal email for official business. AP likewise notes that Fauci has not been charged in Morens’ case. 

So I would resist the tempting leap:

Morens guilty → lab leak proven.

That inference is logically invalid.

The warranted inference is narrower but still consequential:

Morens guilty → the documentary record surrounding the origins debate was deliberately compromised → confidence in earlier institutional representations must be recalibrated → previously dismissed questions deserve examination on their evidence rather than on institutional authority.

That is already a very big deal.

There is another detail I find especially troubling. DOJ says that Morens and the EcoHealth-linked co-conspirator also conspired concerning illegal gratuities: wine was sent for his “behind-the-scenes” assistance, and Morens identified writing a scientific commentary advocating a natural origin as an official act he could perform. 

Again, that does not make the natural-origin hypothesis scientifically false.

But epistemologically it is poisonous.

Because a scientific proposition should ideally stand like this:

evidence → conclusion.

Once you discover behind it:

friendship + grant advocacy + institutional reputation + private channels + gifts + public scientific commentary,

you must reopen the question of whether motivated reasoning and institutional self-protection contaminated the epistemic process.

And here I think the Morens affair becomes larger than COVID.

During an emergency, experts understandably say:

Trust us; there isn’t time for everyone to reconstruct the evidence independently.

That creates an enormous ethical obligation on experts:

Then you must be more transparent than usual, not less.

Instead, what Morens has admitted is behavior in the opposite direction—because the issue was politically and institutionally sensitive, relevant government communications were intentionally moved outside normal public-record channels. 

That is precisely how institutional trust gets destroyed.

So if I were to summarize the implication today, August 19, 2026, in four lines:

It does not prove lab leak.
It does prove deliberate concealment of relevant federal records.
That makes blanket appeals to NIAID/NIH institutional authority considerably weaker.
And it makes reopening the COVID-origin evidentiary record intellectually legitimate rather than “conspiratorial.”

There is an irony here that is worth emphasizing. If officials feared that disclosure would give oxygen to conspiracy theories, concealing the records was probably the most effective imaginable way of creating the conditions in which conspiracy theories flourish. Institutions cannot simultaneously say “trust the science” and privately decide which parts of the scientific-administrative record the public is allowed to see.

The Morens plea is therefore less, at present, a solution to the COVID-origin question than an indictment of how the question was governed

Given that this case is still developing toward sentencing and may produce further testimony or documents, I can monitor it and flag any development that materially changes what we know about Morens, Fauci, EcoHealth, or the COVID-origin record.


David Morens, former NIAID adviser, pleads guilty in COVID-19 records scheme

 https://www.cbsnews.com/news/david-morens-niaid-pleads-guilty-covid-records/

Former Senior NIAID Official Pleads Guilty to Charges Connected to Concealing Federal Records During COVID-19 Pandemic

https://www.justice.gov/usao-md/pr/former-senior-niaid-official-pleads-guilty-charges-connected-concealing-federal-records

美國國家過敏症和传染病研究所(NIAID)前所長安東尼·福奇(Anthony Fauci)的前高級顧問戴維·莫倫斯(David Morens)於2026年8月18日正式認罪,承認在新冠疫情期間與他人合謀隱瞞、刪除聯邦記錄及規避《資訊自由法》(FOIA)調查。詳細資訊可參考美國司法部馬里蘭聯邦檢察官辦公室的官方公告。 [123]
認罪核心事實
  • 違法行為:莫倫斯承認利用私人電子郵件信箱和通訊軟體,故意避開政府的公共紀錄與審查法律。
  • 隱瞞內容:企圖掩蓋與新冠肺炎研究補助金(包含爭議性冠狀病毒研究計畫)相關的討論與文件。
  • 私下利益:承認曾利用職權為特定外部人士及公司謀利,並藉此收受葡萄酒與高檔餐廳餐點等好處。 [1234]
後續與影響
  • 調查進展:此案由美國司法部與聯邦調查局(FBI)等機構共同調查並達成認罪協商。
  • 國會審查:該案件加深了美國國會共和黨人對聯邦疫情應對機制及透明度的持續追究。 [1234]