Abilify (aripiprazole) is an atypical antipsychotic often used to treat conditions like schizophrenia, bipolar disorder, and sometimes major depressive disorder when used as an adjunct. Its safety in pregnancy, however, is still not fully established, and it should be used with caution.
What We Know About Abilify (Aripiprazole) in Pregnancy
1. Limited Data: Research on aripiprazole use during pregnancy is limited. Available studies do not show a strong association with major birth defects, but data are not comprehensive, and risks cannot be fully ruled out.
2. Potential Risks:
• Neonatal Adaptation Syndrome: Babies exposed to antipsychotics, including aripiprazole, in the third trimester may experience symptoms such as agitation, feeding difficulties, or respiratory distress after birth. This is sometimes referred to as neonatal adaptation syndrome, which can result from withdrawal or effects of the drug.
• Gestational Diabetes: Some antipsychotics are associated with an increased risk of gestational diabetes. Although aripiprazole is less likely to cause weight gain compared to other antipsychotics, monitoring for metabolic changes is generally advised during pregnancy.
3. Use When Benefits Outweigh Risks: Abilify is sometimes prescribed during pregnancy when the benefits to the mother outweigh the potential risks to the fetus. Untreated mental health conditions (like severe psychosis or bipolar disorder) can also pose significant risks, such as poor prenatal care, increased risk of self-harm, or postpartum complications. Therefore, maintaining stable mental health is often a priority, and in some cases, aripiprazole may be necessary.
Recommendations for Use
• Close Monitoring: If aripiprazole is deemed necessary, healthcare providers will typically monitor the mother and fetus closely, especially in the later stages of pregnancy, to watch for any signs of neonatal adaptation syndrome or metabolic changes.
• Alternatives: Depending on the condition being treated, healthcare providers may consider other medications or therapies with more established safety profiles, if appropriate.
Consult Your Healthcare Provider
Because each case is unique, pregnant individuals or those planning pregnancy should consult their healthcare provider before starting or continuing aripiprazole. Decisions about medication use in pregnancy should always involve a thorough risk-benefit analysis tailored to the individual’s mental health needs and overall health.
