http://alert.psychnews.org/2018/12/study-identifies-some-predictors-of.html
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18040461
Bipolar disorder in individuals at familial risk typically unfolds in a progressive clinical sequence. Childhood sleep and anxiety disorders are important predictors, as are clinically significant mood symptoms and psychotic symptoms in depressive episodes.