Brexpiprazole (brand name Rexulti) is a prescription medication primarily used to treat conditions such as schizophrenia and as an adjunctive treatment for major depressive disorder (MDD). It belongs to a class of drugs called atypical antipsychotics and works by modulating certain brain chemicals like dopamine and serotonin. Below is a guide on how to use brexpiprazole effectively:
1. General Guidelines
• Follow your doctor’s instructions: Always take brexpiprazole exactly as prescribed by your healthcare provider.
• Form: Brexpiprazole is available as oral tablets in various strengths (e.g., 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg).
• Take at the same time each day: This helps maintain consistent drug levels in your system.
2. Dosage Information
For Schizophrenia:
• Initial dose: 1 mg once daily.
• Titration: The dose is usually increased to 2 mg once daily on Day 4, and then possibly to 4 mg based on individual response and tolerability.
• Maintenance dose: 2–4 mg once daily.
• Maximum dose: 4 mg per day.
For Major Depressive Disorder (Adjunctive Therapy):
• Initial dose: 0.5–1 mg once daily as an adjunct to antidepressants.
• Titration: The dose may be increased to 2 mg once daily based on clinical response and tolerability.
• Maximum dose: 3 mg per day.
3. How to Take It
• With or without food: Brexpiprazole can be taken with or without meals.
• Do not crush or chew: Swallow the tablet whole with water.
• Missed dose: If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up.
4. Precautions
• Avoid abrupt discontinuation: Stopping brexpiprazole suddenly can lead to withdrawal symptoms or worsening of your condition. Always taper off under medical supervision.
• Alcohol and sedatives: Avoid alcohol or sedatives, as they can increase drowsiness or impair cognitive function.
• Driving or operating machinery: Brexpiprazole may cause drowsiness, dizziness, or impair judgment; be cautious.
• Weight monitoring: The medication can cause weight gain, so regular monitoring is advised.
5. Potential Side Effects
Common Side Effects:
• Weight gain
• Drowsiness or fatigue
• Restlessness (akathisia)
• Increased appetite
• Dizziness
Serious Side Effects:
• Suicidal thoughts or behaviors (especially in young adults)
• Signs of allergic reaction (rash, itching, swelling, difficulty breathing)
• Uncontrolled movements (tardive dyskinesia)
• Severe mood or behavioral changes
If you experience severe side effects, contact your healthcare provider immediately.
6. Special Considerations
• Pregnancy and breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Pre-existing conditions: Share your medical history, especially if you have diabetes, heart disease, a history of seizures, or liver/kidney problems.
• Drug interactions: Brexpiprazole can interact with other medications, such as antihypertensives, antidepressants, or antiepileptic drugs, so ensure your doctor is aware of all medicines you are taking.
7. Monitoring
• Regular follow-ups with your doctor are necessary to monitor:
• Mental health symptoms (response to treatment).
• Side effects or potential complications.
• Weight, glucose, and cholesterol levels.
Conclusion
Brexpiprazole is a versatile medication for treating mental health conditions but requires careful adherence to prescribed instructions. Always consult your healthcare provider for personalized advice, especially regarding dosage adjustments or managing side effects.
